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What factor is thrombin?

Asked by: Frits Bogesch

asked in category: General Last Updated: 9th March, 2020

What factor is thrombin?

Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with platelets from the blood, forms a clot.

Also question is, which factors are activated by thrombin?

Thrombin is the principal enzyme of hemostasis. It catalyzes the conversion of fibrinogen to fibrin and activates procoagulant factors V, VIII, XI, and XIII. Additionally, when bound to thrombomodulin, it activates protein C, an anticoagulant zymogen.

Additionally, what are the 13 blood clotting factors? The following are coagulation factors and their common names:

  • Factor I – fibrinogen.
  • Factor II – prothrombin.
  • Factor III – tissue thromboplastin (tissue factor)
  • Factor IV – ionized calcium ( Ca++ )
  • Factor V – labile factor or proaccelerin.
  • Factor VI – unassigned.
  • Factor VII – stable factor or proconvertin.

Thereof, what are procoagulant factors?

Procoagulant cofactors are tissue factor, factor V, factor VIII, and HMWK. Cofactors of the coagulation control proteins are thrombomodulin, protein S, and protein Z (Table 35.10). Vessel injury exposes blood to the subendothelial tissue factor-bearing cells and leads to activation of coagulation through VIIa.

Is Thrombin a blood product?

Thrombin is available as a stand-alone product and is also a component of other biologic hemostatic agents. Bovine-derived thrombin actively promotes coagulation by converting fibrinogen to fibrin and activating platelets.

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